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The Kidney Stone Page |
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PROTEIN
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ABSTRACT
Giannini S, Nobile M, Sartori L, Dalle Carbonare L, Ciuffreda M, Corro P, D'Angelo A, Calo L, Crepaldi G
Division of Nephrology, University of Padova and the National Research Council Centre for Aging Studies of Padova, Italy. giannini@ux1.unipd.it
BACKGROUND:
High dietary protein intake is a potential risk factor for nephrolithiasis
because of its capacity to increase urinary calcium and to facilitate
lithogenesis through many other mechanisms.
OBJECTIVE:
Our aim was to verify the effects of moderate protein restriction in hypercalciuric patients.
DESIGN:
We studied 18 patients (10 men and 8 women aged 45.6+/-12.3 y) with idiopathic hypercalciuria and renal calculi. Before and after 15 d of a diet with 0.8 g protein x kg(-1) x d(-1) and 955 mg Ca, all patients were evaluated for the main serum and urinary measures of calcium metabolism as well as for urinary uric acid, oxalate, citrate, and prostaglandin E2.
RESULTS:
Urinary excretion of urea fell after the diet (P < 0.001). Urinary calcium (P < 0.001), uric acid (P < 0.005), oxalate (P < 0.01), and hydroxyproline (P < 0.01) decreased after protein restriction, whereas urinary citrate increased (P < 0.025).
Blood pH increased after the hypoproteic diet (P < 0.05). 1,25-Dihydroxycholecalciferol (calcitriol) concentration fell significantly (P < 0.025) and parathyroid hormone increased (P < 0.001). Creatinine clearance tended to decrease (106.4+/-4.8 compared with 97.5+/-5.7 mL/min) after the diet. The decrease in urinary uric acid after the diet correlated with calcitriol concentration (r = 0.57, P < 0.05) and the decrease in urinary urea correlated positively with that in hydroxyproline excretion (r = 0.58, P < 0.01).
CONCLUSIONS:
In hypercalciuric patients, moderate protein restriction decreases calcium excretion, mainly through a reduction in bone resorption and renal calcium loss; both are likely due to a decreased exogenous acid load. Moreover, dietary protein restriction ameliorates the entire lithogenic profile in these patients.
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This information is not intended to diagnose, treat, cure or prevent any disease.
If you need medical attention, consult your health care professional.
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